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Serum or plasma concentration of total protein (mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins. Proteins help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Total protein levels can indicate overall health, hydration status, or potential protein-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
7460-9
Short code
Lettuce IgG Qn
Synonyms
Lettuce IgG Qn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like dehydration, liver disease, kidney problems, or malnutrition. It can also help diagnose or monitor certain diseases, such as multiple myeloma or severe infections.

What Does a Low or High Total Protein Level Mean?

Low levels might suggest dehydration, malnutrition, liver disease, or kidney issues. High levels could indicate dehydration, inflammation, or conditions like multiple myeloma or severe infections.

How Is the Test Performed?

A blood sample is taken from a vein, usually in your arm. The sample is then sent to a lab where it is analyzed to measure the total protein concentration.

What Are Common Reference Ranges?

Reference ranges can vary by lab and may not be provided here due to variability. Your results will be compared to your specific lab’s standards.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Total protein levels can reflect underlying health conditions. Dehydration or severe infections may cause elevated levels, while conditions like liver disease or kidney problems can lead to lower levels. Monitoring protein levels helps guide treatment decisions.

Short name

Total Protein

Frequently asked questions

What does a total protein test measure?
It measures the combined amount of all proteins in your blood, which includes albumin and globulins. This helps assess overall protein status and potential health issues.
Can diet affect my total protein test results?
Yes, diet can influence protein levels. High-protein diets or certain medical conditions may temporarily alter results. Your healthcare provider will consider your overall health and medical history.
How often should I get a total protein test?
Frequency depends on your medical condition and healthcare provider’s recommendations. Some people may need this test annually or more often if they have ongoing health concerns.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy