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Cerebrospinal Fluid Leucine Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of the amino acid leucine in your cerebrospinal fluid (CSF), the clear fluid that surrounds your brain and spinal cord. Leucine is involved in protein synthesis and muscle function.

Quick summary

["Leucine levels in CSF can help diagnose or monitor conditions affecting the central nervous system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9412-8
Short code
Leucine CSF-sCnc
Synonyms
Leucine CSF-sCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like headaches, confusion, or neurological issues that could indicate an infection, inflammation, or other condition affecting the brain or spinal fluid. It may also be used in research or specialized diagnostic scenarios.

What to Expect Before the Test

You’ll likely undergo a lumbar puncture (spinal tap) to collect the CSF sample. This involves lying on your side and having a needle inserted into your lower back. The procedure is usually quick and may cause mild discomfort. You may be asked to fast before the test, but this depends on your provider’s instructions.

What Happens During the Test

After the needle is inserted, a small amount of CSF is collected into a sterile container. The sample is then sent to a lab for analysis. The test focuses specifically on measuring leucine concentration, which is analyzed using a specialized laboratory technique.

What the Results Mean

Results are reported as a mass concentration of leucine in the CSF. While reference ranges can vary by lab, abnormal levels may suggest conditions like meningitis, metabolic disorders, or other neurological conditions. Your healthcare provider will interpret the results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Leucine Level

Frequently asked questions

How often is this test typically performed?
This test is usually performed only when clinically necessary, often as part of a diagnostic evaluation for suspected neurological conditions. It’s not a routine screening test and may be repeated if your symptoms or treatment plan requires ongoing monitoring.
What are the common symptoms that might lead to this test?
Common symptoms prompting this test include persistent headaches, fever, confusion, seizures, or other neurological symptoms that suggest an underlying issue affecting the brain or spinal fluid. Your doctor may also order it if you have a history of metabolic disorders or genetic conditions.
Are there any risks or side effects associated with this procedure?
The most common side effect is a mild headache or soreness at the injection site, which usually resolves within a few hours. Rarely, there may be bruising or infection at the puncture site. Always follow your healthcare provider’s post-procedure instructions to minimize risks.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy