Leukocyte Esterase in Cerebrospinal Fluid (CSF)

Why This Test Is Done

Your doctor may order this test if you have symptoms such as severe headache, neck stiffness, fever, or confusion. It’s often used alongside other tests, like a lumbar puncture, to investigate possible infections or inflammatory conditions in the central nervous system.

What to Expect Before the Test

No special preparation is needed. The test involves a small needle inserted into your lower back to collect a small amount of CSF. You may feel pressure or a brief sting, but it usually doesn’t cause significant discomfort.

What the Results Mean

A positive result (presence of leukocyte esterase) suggests an active infection or inflammation in the CSF, which could indicate conditions like bacterial meningitis. However, false positives can occur, so results are often interpreted alongside other clinical findings and tests.

Possible Conditions Linked to Positive Results

Positive results may be associated with infections (e.g., bacterial or viral meningitis), inflammatory diseases (e.g., multiple sclerosis), or other conditions causing white blood cell activity in the CSF.