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Cerebrospinal Fluid Protein by Immunoassay (TMB-based)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total protein content in your cerebrospinal fluid (CSF), which is the fluid surrounding your brain and spinal cord. Protein levels can help identify conditions affecting the central nervous system.

Quick summary

["Protein in CSF may signal inflammation, infection, or structural issues in the brain or spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109783-1
Short code
LGI1 Ab Msmt CSF
Synonyms
LGI1 Ab Msmt CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like headaches, neck stiffness, vision changes, or neurological issues that suggest conditions such as meningitis, multiple sclerosis, or brain tumors. It helps assess the health of your central nervous system by examining the fluid around your brain and spinal cord.

What Does the Result Mean?

Protein levels in CSF can vary based on medical conditions. Elevated levels might indicate inflammation, infection, or bleeding in the brain. Lower levels could suggest certain genetic or congenital disorders. Your doctor will interpret the result in the context of your symptoms and other tests.

Common Conditions Affecting CSF Protein Levels

High protein levels in CSF are often linked to conditions like meningitis, encephalitis, or tumors. Low protein levels may be seen in conditions such as cerebral palsy or certain genetic disorders affecting protein synthesis in the central nervous system.

How Is This Test Performed?

A small amount of CSF is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then analyzed in a lab using an immunoassay method to measure protein concentration.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein Level

Frequently asked questions

What preparation is needed before this test?
No special preparation is typically required. You may be asked to avoid certain medications or activities for a short time, depending on your doctor’s instructions. Follow any specific instructions provided by your healthcare team.
Is there any risk or discomfort associated with this test?
The lumbar puncture may cause mild discomfort or temporary soreness at the injection site. There are rare risks, such as headache, infection, or nerve damage, but these are uncommon. Your doctor will discuss potential risks with you before the procedure.
How long does it take to get the results?
Results are usually available within a few days to a week, depending on lab processing times. Your doctor will contact you once the results are ready and will discuss them with you during your follow-up visit.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy