Cerebrospinal Fluid Protein by Immunoassay (TMB-based)
This test measures the total protein content in your cerebrospinal fluid (CSF), which is the fluid surrounding your brain and spinal cord. Protein levels can help identify conditions affecting the central nervous system.
["Protein in CSF may signal inflammation, infection, or structural issues in the brain or spinal cord."]
Key facts at a glance
- LOINC
- 109783-1
- Short code
- LGI1 Ab Msmt CSF
- Synonyms
- LGI1 Ab Msmt CSF
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your doctor may order this test if you have symptoms like headaches, neck stiffness, vision changes, or neurological issues that suggest conditions such as meningitis, multiple sclerosis, or brain tumors. It helps assess the health of your central nervous system by examining the fluid around your brain and spinal cord.
What Does the Result Mean?
Protein levels in CSF can vary based on medical conditions. Elevated levels might indicate inflammation, infection, or bleeding in the brain. Lower levels could suggest certain genetic or congenital disorders. Your doctor will interpret the result in the context of your symptoms and other tests.
Common Conditions Affecting CSF Protein Levels
High protein levels in CSF are often linked to conditions like meningitis, encephalitis, or tumors. Low protein levels may be seen in conditions such as cerebral palsy or certain genetic disorders affecting protein synthesis in the central nervous system.
How Is This Test Performed?
A small amount of CSF is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then analyzed in a lab using an immunoassay method to measure protein concentration.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
CSF Protein Level
Frequently asked questions
What preparation is needed before this test?
Is there any risk or discomfort associated with this test?
How long does it take to get the results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy