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Lipoprotein(a) concentration (Lp(a))

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of lipoprotein(a), a type of cholesterol-like substance that includes both cholesterol and a protein called apolipoprotein(a). It’s important because high levels may increase your risk of heart disease and blood clots.

Quick summary

["Lipoprotein(a) levels help assess cardiovascular risk beyond standard cholesterol tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
83103-2
Short code
LH SerPl IA-aCnc
Synonyms
LH SerPl IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
1.5
Ref high
9
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
83002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Lipoprotein(a)?

Lipoprotein(a) is a unique lipoprotein particle that combines cholesterol with a distinct protein called apolipoprotein(a). Unlike regular cholesterol, Lp(a) has a strong genetic component and can persist at higher levels in some people. It may contribute to plaque buildup in arteries, increasing the risk of heart attacks or strokes.

Why Might You Need This Test?

Your doctor may order this test if you have a family history of early heart disease, unexplained high cholesterol, or symptoms like chest pain or stroke. It’s also sometimes checked in people with conditions like high blood pressure or diabetes, as well as those undergoing preventive cardiovascular screening.

How Is the Test Done?

A blood sample is taken from a vein, usually in your arm. The blood is then processed to measure the concentration of lipoprotein(a) using a specialized immunoassay method. Results are typically available within a few days.

What Do the Results Mean?

High levels of lipoprotein(a) may increase your risk of cardiovascular problems, though results alone don’t diagnose a condition. Your doctor will consider your overall health, including other risk factors like smoking, diabetes, or high blood pressure, when interpreting the results.

Reference range

Follicular: 1.5-9.0 mIU/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Lipoprotein(a) (Lp(a))

Frequently asked questions

What causes lipoprotein(a) levels to be high?
High lipoprotein(a) levels often have a genetic basis, meaning they may run in families. However, certain medical conditions—like kidney disease or high blood pressure—can also influence levels. Lifestyle factors, such as diet or smoking, may play a smaller role but are still worth considering.
Can lifestyle changes lower lipoprotein(a) levels?
While lifestyle changes like improving diet, exercising regularly, and avoiding smoking may help manage other cardiovascular risk factors, there’s limited evidence that they significantly lower lipoprotein(a) levels on their own. Some medications, such as PCSK9 inhibitors, may be explored for people with very high levels.
How often should I get this test?
Your doctor will determine how often you need this test based on your individual risk factors. Typically, it’s not part of routine annual checkups but may be recommended every few years or more frequently if you have a high-risk profile.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy