Skip to content

Lipoprotein(a) concentration (Lp(a))

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of lipoprotein(a), a type of cholesterol-like substance that may increase your risk of heart disease and blood clots.

Quick summary

["Lipoprotein(a) is linked to higher cardiovascular risks and may require monitoring or lifestyle adjustments if elevated."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50516-4
Short code
LH sp8 SerPl-aCnc
Synonyms
LH sp8 SerPl-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
1.5
Ref high
9
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Lipoprotein(a)?

Lipoprotein(a) is a unique lipoprotein particle that combines cholesterol with a protein called apolipoprotein(a). Unlike regular cholesterol, Lp(a) has a strong genetic influence and may persist at higher levels over time. It can build up in arteries, contributing to plaque formation and increasing the risk of heart attacks or strokes.

Why Might You Need This Test?

Your healthcare provider may order this test if you have a family history of heart disease, high cholesterol, or other cardiovascular risks. It may also be checked in people with conditions like atherosclerosis or unexplained blood clots.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to measure Lp(a) levels using a specialized immunoassay method.

What Do Results Mean?

Results show your Lp(a) concentration in milligrams per deciliter (mg/dL). While reference ranges vary by lab, higher levels may signal increased cardiovascular risk, prompting further evaluation or lifestyle guidance.

Reference range

Follicular: 1.5-9.0 mIU/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Lipoprotein(a) (Lp(a))

Frequently asked questions

Why do some people have higher Lp(a) levels than others?
Lipoprotein(a) levels are strongly influenced by genetics. Some people inherit higher Lp(a) from their family, which may not change much over time. While lifestyle factors like diet or exercise can affect cholesterol, Lp(a) is less responsive to these changes.
Can lifestyle changes lower Lp(a) levels?
Currently, there are no proven lifestyle changes or medications that significantly lower Lp(a) levels. However, managing other cardiovascular risk factors—such as cholesterol, blood pressure, and smoking—can still improve overall heart health.
Is Lp(a) tested in the same way as cholesterol?
No, Lp(a) is measured separately using a specialized immunoassay. While cholesterol tests (like LDL or HDL) are common, Lp(a) is often checked only if there’s a known risk for cardiovascular disease or related conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy