24-Hour Urinary Lipase

Why This Test Is Done

Your doctor may order a 24-hour urinary lipase test if they suspect conditions like pancreatitis, pancreatic cancer, or other digestive disorders. It helps assess how well your pancreas is functioning by measuring enzyme activity in urine over a full day, which can reflect ongoing digestive processes.

What to Expect Before the Test

No special preparation is needed beyond collecting a full 24-hour urine sample. You’ll typically start the collection in the morning after emptying your bladder, then collect all urine for the next 24 hours, including during sleep. Store the sample in a refrigerator until you return it to the lab.

What the Test Results Mean

Elevated levels may indicate chronic pancreatitis, pancreatic inflammation, or other digestive issues. Normal results suggest healthy fat digestion. However, results alone aren’t diagnostic—they’re often used alongside other tests and symptoms.

Common Conditions Linked to Abnormal Results

High urinary lipase can signal chronic pancreatitis, pancreatic tumors, or bile duct obstructions. Low or normal results may suggest healthy pancreatic function but don’t rule out acute issues like pancreatitis without additional testing.