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Serum Lipase Activity (Enzymatic)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity of an enzyme called lipase in your blood. Lipase helps break down fats, and elevated levels may signal inflammation or digestive issues.

Quick summary

["Elevated lipase can signal pancreatitis or other digestive problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
3039-5
Short code
Lipase Amn-cCnc
Synonyms
Lipase Amn-cCnc
Category
glucose
Sample
fluid
Container
Sterile tube
Units
N/A
Critical range
— – 1000 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like severe stomach pain, nausea, vomiting, or unexplained weight loss. It’s also used to monitor conditions like pancreatitis, gallbladder disease, or severe pancreatitis after surgery.

What to Expect Before the Test

No special preparation is needed, but avoid eating or drinking for at least 8–12 hours before the test if instructed. Wear comfortable clothing and fasten your shirt for easy access to your arm.

How the Test Works

A healthcare provider will draw blood from a vein in your arm. The blood sample is sent to a lab, where enzymes break down a fat-containing solution. The test measures how quickly this happens to determine lipase activity.

Possible Results and Next Steps

Results are typically reported as a ratio or relative activity compared to a standard. High levels may trigger further testing, like additional bloodwork or imaging, to investigate the cause of your symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Elevated lipase is strongly linked to pancreatitis, which can cause severe abdominal pain, fever, and jaundice. It may also indicate other conditions like bile duct obstructions or severe infections.

Short name

Lipase Test

Frequently asked questions

What causes elevated lipase levels?
Common causes include pancreatitis (acute or chronic), gallbladder disease, severe infections, or certain medications. Rarely, it may be elevated in kidney disease or after trauma.
What if my results are normal but I still have symptoms?
Normal results don’t rule out all causes. Your doctor may repeat the test or order additional tests, such as amylase levels or imaging studies, to identify the issue.
Can I take anything for my symptoms before the test?
Avoid over-the-counter pain relievers (like NSAIDs) or strong pain medications for 48 hours before testing, as they may affect results. Always follow your doctor’s instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy