Lipase (Serum or Plasma)

Why Is This Test Done?

Your doctor may order a lipase test to investigate symptoms like severe stomach pain, nausea, vomiting, or unexplained weight loss. It can also help diagnose conditions like pancreatitis, gallbladder disease, or other digestive disorders. Sometimes, it’s used as part of a broader evaluation for unexplained abdominal issues or after exposure to certain toxins or medications that affect digestion.

What to Expect Before the Test

You can eat and drink normally before this test, as it doesn’t require fasting. The blood sample is usually taken from a vein in your arm. If you’re on blood thinners or have a history of bleeding disorders, let your doctor know. Avoid heavy exercise or stress right before the test, as these can sometimes affect results.

What Happens During the Test?

A healthcare professional will clean the area where the needle will go and insert a small needle into your arm to draw blood. The process is quick and usually causes only a minor pinch. The blood is then sent to a lab for analysis. You may feel some discomfort, but it shouldn’t last long.

What Are Possible Results?

Results are typically reported as a concentration of lipase in the blood. While reference ranges can vary by lab, elevated levels (above normal) often indicate acute pancreatitis or other digestive issues. Very low levels may suggest rare conditions like chronic pancreatitis or certain genetic disorders. Your doctor will interpret results in the context of your symptoms and medical history.