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Serum Lipase Activity

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity level of lipase, an enzyme produced by the pancreas that helps break down fats. High levels may signal pancreatitis or other digestive issues.

Quick summary

["Lipase helps your body digest fats, and elevated results often point to pancreatitis or other abdominal problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47418-9
Short code
Lipase Plr-cCnc
Synonyms
Lipase Plr-cCnc
Category
glucose
Sample
fluid
Container
Sterile tube
Units
N/A
Critical range
— – 1000 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order a lipase test to check for inflammation or damage in the pancreas, especially if you have symptoms like severe abdominal pain, nausea, vomiting, or unexplained weight loss. It can also help diagnose conditions like pancreatitis, gallbladder disease, or other digestive disorders.

What Does the Test Involve?

A blood sample is taken from a vein in your arm. The blood is sent to a lab where it is analyzed to measure lipase enzyme activity. No special preparation is usually needed, but you may be asked to avoid certain foods or medications for a short time before testing.

What Are Common Results?

Results are not given in a single numeric range because they depend on the lab’s methods and your health status. Elevated levels (above normal) often indicate acute or chronic pancreatitis, while very low levels may suggest pancreatic insufficiency or other conditions.

What Are Normal Results?

Normal results do not have a universally standardized range due to variations in testing methods. Your doctor will interpret the results in relation to your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

High lipase levels are strongly associated with pancreatitis, a serious inflammation of the pancreas that can cause severe pain, organ damage, or even require hospitalization. Other conditions, such as kidney disease, gallbladder issues, or certain infections, may also cause elevated lipase. Low levels might suggest pancreatic cancer or other rare conditions.

Short name

Lipase Test

Frequently asked questions

What causes elevated lipase levels?
Elevated lipase levels are most commonly caused by pancreatitis (acute or chronic), but they can also result from gallbladder disease, kidney problems, trauma to the abdomen, or certain medications. Symptoms like severe abdominal pain, nausea, or vomiting often accompany these conditions.
What if my lipase level is normal but I still have symptoms?
Even if your lipase test is normal, other tests or imaging may be needed to diagnose the cause of your symptoms. Your doctor may recommend additional tests, such as an amylase test, CT scan, or ultrasound, to get a clearer picture of what’s happening in your body.
Can diet or medications affect lipase levels?
Yes, certain foods (like fatty or spicy meals) and medications (such as certain antibiotics or pain relievers) can temporarily affect lipase levels. Your doctor may advise you to avoid specific foods or medications for a few days before testing to get the most accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy