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Pancreatic Lipase Activity (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity of pancreatic lipase, an enzyme produced by the pancreas that helps break down fats. Elevated levels may indicate pancreatitis or other digestive issues.

Quick summary

["Elevated levels often signal pancreatic inflammation or digestive problems; normal results suggest healthy fat digestion."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35315-1
Short code
Lipase sp3 p sincalide Fld-cCnc
Synonyms
Lipase sp3 p sincalide Fld-cCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
— – 1000 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like severe abdominal pain, nausea, vomiting, or unexplained weight loss. It’s also used to monitor chronic conditions like pancreatitis or cystic fibrosis.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the blood draw. Wear a loose shirt for easy access.

What Happens During the Test?

A healthcare provider will draw blood from a vein in your arm. The process takes a few minutes, and you may feel slight discomfort. The sample is sent to a lab for analysis.

What Do Results Mean?

Results are compared to a reference range, but exact values depend on the lab. High levels may indicate pancreatitis, gallstones, or other digestive disorders. Low levels could suggest pancreatic insufficiency.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Pancreatic Lipase in Diagnosis

Short name

Pancreatic Lipase

Frequently asked questions

Elevated pancreatic lipase is highly specific for acute pancreatitis, often rising within 24 hours of symptoms. It’s also useful for diagnosing chronic pancreatitis or pancreatic cancer, though other conditions (like gallbladder issues) may cause temporary spikes.
This test is not typically used for routine screening but is critical in diagnosing suspected digestive or pancreatic disorders. It helps distinguish between different causes of abdominal pain or digestive symptoms.
What causes elevated pancreatic lipase levels?
Common causes include acute pancreatitis (inflammation of the pancreas), gallstones blocking bile flow, severe abdominal trauma, or certain medications. Chronic conditions like cystic fibrosis or pancreatic cancer may also lead to prolonged elevation.
What if my results are normal but I still have symptoms?
Normal results don’t rule out all causes of symptoms. If you have persistent abdominal pain, nausea, or other concerning signs, your doctor may recommend additional tests (like imaging or further enzyme tests) or repeat this test under different conditions (e.g., after fasting or with contrast agents).
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy