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Lithium concentration in whole blood

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of lithium, a medication, in your blood. Lithium is used to treat certain mental health conditions, such as bipolar disorder.

Quick summary

["Lithium levels help doctors monitor your medication dose and ensure safety."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
25461-5
Short code
Lithium, Bld-sCnc
Synonyms
Lithium, Bld-sCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
0.6
Ref high
1.2
Critical range
— – 1.6 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order a lithium blood test if you’re taking lithium medication to manage conditions like bipolar disorder or depression. Regular testing helps track your medication levels to prevent side effects or ensure it’s working properly.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if instructed by your doctor. Bring a list of all medications, including over-the-counter drugs and supplements, to share with your provider.

During the Test

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a brief pinch, but the procedure usually takes less than 5 minutes. The blood sample is then sent to a lab for analysis.

After the Test

You can return to your normal activities immediately. There may be mild bruising or soreness at the injection site, but this typically resolves within a few days. If you experience unusual bleeding, excessive pain, or signs of infection, contact your provider.

Reference range

Therapeutic: 0.6-1.2 mmol/LN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Lithium levels help doctors determine if your medication dose is too high or too low. High levels can cause nausea, confusion, or even serious health risks, while low levels may mean the medication isn’t working effectively. Regular monitoring ensures safe and optimal treatment.

Short name

Lithium Blood Level

Frequently asked questions

How often should I get this test?
Your doctor will schedule lithium blood tests based on your treatment plan. Typically, tests are done every few weeks or months to adjust your dose if needed, especially when starting, changing, or stopping lithium.
What does a low or high lithium level mean?
A low lithium level may indicate the medication isn’t working as intended, while a high level could signal toxicity. Your doctor will discuss results with you and adjust your treatment plan if necessary.
Can I eat or drink before the test?
Most providers recommend fasting for 8–12 hours before the test, but always follow your doctor’s specific instructions to avoid interfering with results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy