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Serum Lithium-Free Protein Concentration (or Protein Content)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of protein in your blood that is not bound to lithium, a medication used to manage certain mental health conditions. It helps assess how your body processes lithium.

Quick summary

["Understanding your protein levels without lithium can aid in monitoring medication effects and kidney function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
80970-7
Short code
Lithium free SerPl-sCnc
Synonyms
Lithium free SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.6
Ref high
1.2
Critical range
— – 1.6 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re taking lithium to check how well your body is handling it. It can also help evaluate kidney function indirectly, as lithium is filtered by the kidneys.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. The test is quick and typically done in a lab setting.

What the Results Mean

Results show the concentration of protein that isn’t bound to lithium. High or low levels may indicate how your body processes lithium or if there are kidney-related issues.

Common Causes of Abnormal Results

Changes in protein levels without lithium could be linked to kidney disease, dehydration, or certain medications. Your provider will discuss these with you based on your full medical picture.

Reference range

Therapeutic: 0.6-1.2 mmol/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is primarily used as a supportive measure when lithium levels are being monitored. It doesn’t replace direct lithium measurements but can help assess broader health factors affecting lithium metabolism.

Short name

Lithium-Free Protein Level

Frequently asked questions

Why might my doctor want to check this test?
Your doctor may order this test to help evaluate how well your kidneys are working or to monitor how your body processes lithium, especially if you have kidney concerns or take lithium long-term.
Is there any risk or discomfort with this test?
There’s usually minimal discomfort from a blood draw, but you might feel slight pain or bruising at the site. Rarely, there could be mild swelling or bleeding.
How often should I get this test?
Your doctor will determine the frequency based on your lithium treatment and overall health. It’s often done alongside other tests, like lithium level checks, as part of a broader evaluation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy