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Lithium concentration in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of lithium, a medication, in your blood. Lithium is often prescribed to manage certain mental health conditions.

Quick summary

["Lithium levels help doctors monitor your medication dose and ensure it stays within safe ranges."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
15369-2
Short code
Lithium Sal/SerPl
Synonyms
Lithium Sal/SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.6
Ref high
1.2
Critical range
— – 1.6 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order a lithium test if you’re taking lithium-based medications, such as lithium carbonate or lithium citrate, to treat conditions like bipolar disorder or severe depression. They may also check it if you have symptoms like confusion, nausea, or unusual thirst, which could indicate lithium levels are too high or too low.

What to Expect Before the Test

No special preparation is needed for this test. You’ll have a small needle inserted into your arm or vein to draw a blood sample. The process is quick and usually painless. If you’re on lithium, your provider may ask you to stop taking it temporarily before the test, so let your doctor know if you’re unsure.

What the Test Results Mean

Lithium levels are checked to ensure they’re within the target range for your treatment. Too much lithium can cause side effects like vomiting, tremors, or kidney problems, while too little may mean your medication isn’t working effectively. Your results will be discussed with your healthcare provider, who will adjust your dose if needed.

Common Side Effects of Lithium

Lithium can cause mild side effects like nausea, dizziness, or increased thirst. If you experience severe symptoms like seizures, irregular heartbeat, or signs of kidney problems (e.g., swelling, changes in urine), seek medical attention immediately.

Reference range

Therapeutic: 0.6-1.2 mmol/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Lithium Level

Frequently asked questions

What symptoms might indicate abnormal lithium levels?
Symptoms of **too much lithium** (hyperlithium) include vomiting, diarrhea, confusion, tremors, or muscle weakness. Symptoms of **too little lithium** (hypolithium) may not cause noticeable symptoms but could mean your medication isn’t working as intended.
How often should I get this test?
Your provider will determine how often you need lithium level checks based on your treatment plan, how long you’ve been on lithium, and your overall health. Typically, tests are done every few weeks or months to monitor your levels closely.
Can I drink water before the test?
Yes, you can drink water before the test unless your provider instructs otherwise. Avoid excessive fluids or foods that might affect your blood composition, but no special preparation is required beyond standard hydration.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy