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Lithium concentration in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of lithium, a medication, in your blood. Lithium is often used to treat certain mental health conditions.

Quick summary

["Lithium helps manage mood disorders but must be carefully monitored to avoid side effects."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
3719-2
Short code
Lithium SerPl-mCnc
Synonyms
Lithium SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.6
Ref high
1.2
Critical range
— – 1.6 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check if your lithium levels are within a safe range. This is especially important if you’re taking lithium to treat conditions like bipolar disorder or depression. Regular monitoring helps prevent toxicity or inadequate medication levels.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on lithium, your provider may ask you to stop taking it temporarily before the test, depending on your situation.

What the Results Mean

Results are compared to a general reference range for lithium in blood. Too much lithium can cause serious health problems, while too little may mean your medication isn’t working as intended. Your provider will discuss these details with you.

Possible Side Effects or Risks

Blood tests are generally safe, but drawing blood can cause mild discomfort or bruising. Rarely, lithium levels that are too high can lead to nausea, confusion, or other symptoms, so it’s important to follow your provider’s instructions carefully.

Reference range

Therapeutic: 0.6-1.2 mmol/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Lithium levels are critical for managing psychiatric conditions. Abnormally high levels can cause toxicity, leading to seizures, kidney damage, or other serious issues. Low levels may indicate poor medication adherence or absorption. Regular monitoring ensures your treatment remains effective and safe.

Short name

Lithium Level

Frequently asked questions

How often should I get this test?
Your healthcare provider will determine the timing based on your treatment plan. Typically, tests are done every few weeks or months to monitor lithium levels, especially if you’re new to the medication or have changes in your health.
What happens if my lithium level is too high?
If your lithium level is elevated, your provider may adjust your dose, suggest hydration, or recommend temporary discontinuation. Severe toxicity requires immediate medical attention and may involve hospitalization.
Can I drink alcohol before this test?
Alcohol can affect lithium absorption and may interfere with test results. Your provider will advise you on whether to avoid alcohol before testing, depending on your specific situation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy