Total Bilirubin with Direct and Indirect Fractions (Serum)

Why This Test Matters

Bilirubin is a yellow pigment produced when your body breaks down old red blood cells. Normally, your liver removes it from your bloodstream and sends it to your bile ducts for excretion. If your liver isn’t working properly, bilirubin can build up, leading to jaundice (yellowing of the skin and eyes). This test helps doctors diagnose conditions like hepatitis, gallbladder issues, or hemolytic anemia.

Indirect vs. Direct Bilirubin

Indirect bilirubin is not yet processed by your liver and travels freely in your blood. Direct bilirubin has been chemically altered by your liver and is bound to proteins. High indirect levels often suggest red blood cell breakdown, while high direct levels may indicate liver or bile duct problems.

Sample Collection and Preparation

A blood sample is drawn from a vein in your arm. The test measures bilirubin levels in your serum (liquid part of blood after clotting). No special preparation is needed, but fasting may be advised depending on your doctor’s instructions.

Common Conditions Monitored

Doctors use this test to diagnose or monitor conditions like jaundice, liver disease (e.g., cirrhosis, hepatitis), bile duct blockages, or hemolytic anemia. It’s also used to check for genetic disorders affecting bilirubin metabolism.