Genetic test for mutations in the MUTYH gene (MUTYH-associated polyposis screening)
This test checks for mutations in the MUTYH gene, which may increase your risk of developing colorectal cancer or other polyposis-related conditions. It’s often used in families with a history of such cancers.
["This test helps identify inherited genetic changes linked to a higher risk of colorectal cancer."]
Key facts at a glance
- LOINC
- 35297-1
- Short code
- LMNA gene Mut Anl Bld/T
- Synonyms
- LMNA gene Mut Anl Bld/T
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have a family history of colorectal cancer, multiple polyps in your colon, or other hereditary cancer syndromes. It’s also sometimes used in genetic counseling for at-risk relatives.
What to Expect Before the Test
You’ll typically provide a blood sample, which is sent to a lab for genetic analysis. No special preparation is needed, but discuss any medications with your provider before testing.
What the Results Mean
Results can be normal (no mutations detected) or positive (mutations found). A positive result means you may have an increased risk of colorectal cancer or polyposis, and further evaluation (like colonoscopy) may be recommended.
Next Steps After Testing
If mutations are found, your healthcare team will discuss next steps, which may include monitoring, preventive procedures (like colonoscopy), or genetic counseling to guide family planning.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Mutations in the MUTYH gene are linked to a condition called MUTYH-associated polyposis (MAP), which increases the risk of developing hundreds of polyps in the colon, leading to colorectal cancer. Early detection through genetic testing and monitoring can help manage risk and prevent complications.
Short name
MUTYH Gene Mutation Test
Frequently asked questions
What does a positive result mean for my health?
Will this test affect my insurance or ability to get treatment?
Can I stop taking medications before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy