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Total Protein in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Total protein helps assess kidney function and overall protein balance in your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
3279-7
Short code
LMWK PPP IA-mCnc
Synonyms
LMWK PPP IA-mCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like kidney disease, liver problems, malnutrition, or certain infections. It can also help monitor long-term health in people with chronic illnesses.

What Does a Result Mean?

Higher than expected levels might suggest liver disease, dehydration, or certain cancers. Lower levels could indicate kidney disease, malnutrition, or severe infections.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum (liquid part after clotting) or plasma (liquid part without clotting) for testing.

Common Conditions Monitored

This test is often used to monitor conditions like chronic kidney disease, liver cirrhosis, or to evaluate protein loss in urine (proteinuria).

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes abnormal total protein levels?
Abnormal results can be due to medical conditions like kidney disease, liver disease, infections, or certain cancers. Lifestyle factors such as diet and hydration can also play a role.
How often should I get this test?
The frequency depends on your health condition and why the test was ordered. Your healthcare provider will determine the best schedule for you.
Can diet affect my total protein test results?
Yes, diet can influence protein levels. Eating a balanced diet rich in proteins may affect your results. Avoid consuming large amounts of protein just before your test if instructed by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy