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Total IgE (Immunoglobulin E) Level

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin E (IgE) in your blood. IgE is a type of antibody that plays a role in allergic reactions and responses to certain parasites.

Quick summary

["IgE helps identify allergies or immune responses to triggers like pollen, food, or environmental allergens."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
39546-7
Short code
Lobster IgE/IgE total %
Synonyms
Lobster IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Immunoglobulin E (IgE)?

IgE is a protein produced by your immune system in response to allergens (substances like pollen, pet dander, or certain foods) or parasitic infections. While IgE is usually low in healthy individuals, elevated levels can signal allergies, asthma, or other immune-related conditions.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like sneezing, itching, skin rashes, or breathing difficulties that suggest allergies. It can also help diagnose conditions like allergic asthma, eczema, or certain parasitic infections.

How Is the Test Performed?

A small blood sample is taken from a vein in your arm. The blood is then sent to a lab where it is analyzed to measure IgE levels using an immunoassay method, which detects the presence and quantity of IgE antibodies.

What Do Results Mean?

Results are typically reported in International Units per milliliter (IU/mL). High IgE levels may indicate allergies or immune hyperactivity, while very low levels might suggest a weakened immune response to allergens. Your doctor will interpret results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Elevated IgE Levels

Short name

IgE Total

Frequently asked questions

How often do I need this test?
IgE testing is often done once, but your doctor may recommend follow-up tests if symptoms persist or change. If you have recurring allergies or chronic conditions like asthma, they may schedule periodic checks.
What are the most common causes of high IgE levels?
Common causes include allergies to foods, pollen, dust mites, or pets; allergic asthma; eczema; or parasitic infections. Rarely, high IgE levels can be linked to autoimmune diseases or certain blood disorders.
Can IgE levels be affected by medications?
Yes, some medications like antihistamines, corticosteroids, or immune-suppressing drugs may temporarily lower IgE levels or affect test results. Always inform your doctor about all medications you’re taking before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy