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Total Cholesterol (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of cholesterol in your blood serum. Cholesterol is a type of fat your body needs for healthy cell function, but high levels can increase your risk of heart disease.

Quick summary

["Your cholesterol levels help assess heart health and risk of cardiovascular disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61302-6
Short code
London Plane IgE/IgE total %
Synonyms
London Plane IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check your overall cholesterol levels, monitor existing heart health conditions, or evaluate risk factors for conditions like high blood pressure or diabetes. It’s often part of a broader lipid panel that also includes HDL, LDL, and triglycerides.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 9–12 hours before the test if it’s part of a lipid panel. Bring any medications you’re currently taking, as some can affect cholesterol levels.

How the Test Works

A blood sample is drawn from a vein, usually in your arm. The blood is then sent to a lab where it’s analyzed to measure total cholesterol. The test looks for all types of cholesterol combined, including HDL (good cholesterol) and LDL (bad cholesterol).

What the Results Mean

Results are typically reported as a total cholesterol number (e.g., 200 mg/dL). While exact ranges vary by lab, higher-than-normal levels may signal increased risk for heart disease or stroke, prompting lifestyle changes or further testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Total cholesterol is a key marker for cardiovascular risk. While it doesn’t directly indicate heart disease, it helps doctors assess whether your cholesterol levels are healthy or need intervention. High cholesterol often requires dietary adjustments, exercise, or medication to lower LDL and improve overall heart health.

Short name

Total Cholesterol

Frequently asked questions

What causes high cholesterol?
High cholesterol can result from genetics, poor diet (high in saturated fats), lack of physical activity, obesity, or certain medical conditions like diabetes. Lifestyle factors like smoking and excessive alcohol use may also play a role.
How can I lower my cholesterol naturally?
Eating a heart-healthy diet (rich in fruits, vegetables, whole grains, and lean proteins), exercising regularly, maintaining a healthy weight, and avoiding smoking can help improve cholesterol levels over time.
Do I need to fast before this test?
Yes, if your doctor ordered this test as part of a lipid panel, fasting for 9–12 hours before the blood draw is usually required to get accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy