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Serum or Plasma Substance Concentration by Immunoassay (e.g., for a specific protein or hormone)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of a particular substance in your blood, often used to check for conditions affecting protein levels, hormones, or other biomarkers.

Quick summary

["This test helps diagnose or monitor conditions by detecting abnormal levels of specific substances in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
15285-0
Short code
London Plane IgE Qn
Synonyms
London Plane IgE Qn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects the concentration of a specific substance (e.g., a protein, hormone, or enzyme) in your serum or plasma. The exact substance depends on the clinical indication, such as monitoring thyroid function, detecting infections, or evaluating metabolic disorders. The method used is typically an immunoassay, which identifies and quantifies the substance with high sensitivity and accuracy.

Common Uses

This type of test is commonly used to diagnose or manage conditions like hormone imbalances (e.g., thyroid disorders), infections (e.g., viral markers), or diseases affecting protein synthesis (e.g., liver or kidney conditions). It may also be used in research or specialized clinical settings for rare or niche biomarkers.

Sample Collection and Preparation

Blood is drawn from a vein in your arm, and the sample is processed to separate serum (if clotted) or plasma (if anticoagulated). The test then analyzes the fluid for the target substance using immunoassay techniques, which may involve antibodies binding to the substance to measure its concentration.

When You Might Need This Test

Your healthcare provider may recommend this test if you have symptoms or risk factors for conditions linked to the substance being measured, such as unexplained fatigue, weight changes, or abnormal lab results from other tests. It may also be part of routine monitoring for chronic conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Frequently asked questions

Why might my results be important?
Abnormal results can signal underlying health issues, such as low or high levels of the measured substance, which may require further medical evaluation or treatment adjustments. For example, elevated hormone levels might indicate hyperactivity of a gland, while low levels could suggest deficiency or dysfunction. Always discuss your results with your healthcare provider to understand their implications for your health.
How do I prepare for this test?
No special preparation is usually needed, but avoid eating or drinking (except water) for a specified period before the test if instructed by your provider. Follow any general guidelines, such as fasting if required for the specific analyte being tested.
What are the typical reference ranges?
Reference ranges vary depending on the specific substance being tested. Your healthcare provider will interpret the results in relation to the standard values relevant to your condition and demographic. These ranges may change over time as medical knowledge evolves.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy