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Total Protein with Albumin and Globulin Fractionation (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures total protein in your blood and breaks it down into albumin and globulin fractions, which help assess protein balance and potential issues like malnutrition or liver/kidney problems.

Quick summary

["Understanding your protein balance can help identify health concerns early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
64969-9
Short code
London Plane (rPla a) 1 IgE Qn
Synonyms
London Plane (rPla a) 1 IgE Qn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Total protein reflects the overall amount of protein in your blood, while albumin and globulin give insight into specific protein functions. Albumin, produced by your liver, helps maintain fluid balance and carries important substances. Globulins, which include antibodies and transport proteins, support immune function and hormone transport. Together, these components help your body function properly.

What to Expect During the Test

You’ll have a small needle inserted into your arm to draw blood. The sample is processed to separate protein fractions. Results are typically ready within 24–48 hours.

Common Causes for Testing

Doctors may order this test if you have symptoms like swelling, unexplained weight loss, fatigue, or if they suspect conditions like liver disease, kidney disease, or malnutrition.

What the Results Mean

Abnormal results may indicate conditions such as protein loss (e.g., kidney disease), liver dysfunction, or nutritional deficiencies. Your doctor will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Abnormal protein levels can signal underlying health issues, such as chronic kidney disease (low albumin), liver disease (elevated globulins), or severe infections (increased acute-phase globulins). Monitoring these fractions helps guide treatment decisions.

Short name

Protein profile test

Frequently asked questions

How long does it take to get my results?
Results are usually available within 24–48 hours, but timing may vary depending on your lab’s schedule. Your doctor will contact you once they’re ready.
What should I do if my results are abnormal?
Your doctor will discuss the findings with you and may recommend further testing or changes to your treatment plan. Follow their advice closely.
Can I eat or drink before this test?
You can eat and drink normally unless instructed otherwise. This test only requires a blood sample, so fasting isn’t needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy