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HIV Genotypic Resistance Testing (Lopinavir Resistance)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic changes in the HIV virus that may make it resistant to the medication lopinavir, helping doctors adjust treatment plans if needed.

Quick summary

["Assesses whether HIV may resist lopinavir, guiding potential treatment adjustments."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
41031-6
Short code
Lopinavir Islt Genotyp
Synonyms
Lopinavir Islt Genotyp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
genotyping
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test analyzes specific genes in the HIV virus to identify mutations that could reduce the effectiveness of lopinavir, a medication used to treat HIV. It focuses on the protease and integrase regions of the virus’s genetic material.

Why It’s Done

Your doctor may order this test if you’re taking lopinavir and show signs of treatment resistance, such as persistent viral load or symptoms despite therapy. It helps ensure your treatment remains effective.

How It Works

A small blood sample is taken to extract viral genetic material. Advanced laboratory techniques (like high-performance liquid chromatography or immunoassay) detect any mutations linked to lopinavir resistance.

What to Expect Before the Test

No special preparation is needed. A simple blood draw is all that’s required. If you’re on blood-thinning medication, let your doctor know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HIV Genotype for Lopinavir Resistance

Frequently asked questions

When might I need this test?
This test is typically recommended if you’re on lopinavir-based therapy and experience ongoing viral activity (high viral load) or symptoms despite treatment, or if your doctor suspects resistance.
How long will results take?
Results are usually available within 1 to 2 weeks, depending on lab processing times. Your doctor will discuss them with you during your follow-up visit.
Can I stop lopinavir if this test shows resistance?
Not necessarily. Resistance testing guides treatment adjustments, not necessarily stopping lopinavir. Your doctor will work with you to switch to a different medication or combination that avoids resistant virus strains.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy