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Lipoprotein(a) Cholesterol, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures cholesterol carried by lipoprotein(a), a genetically influenced LDL-like particle, to help assess cardiovascular risk.

Quick summary

["An elevated lipoprotein(a) result may increase cardiovascular risk even when standard LDL cholesterol is not high."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35388-8
Short code
Lpa Cholest SerPl-mCnc
Synonyms
Lpa Cholest SerPl-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test measures the amount of cholesterol carried by lipoprotein(a), also called Lp(a). Lp(a) is an LDL-like particle that includes a protein called apo(a).

Why might I need this test?

The test may be used to assess inherited cardiovascular risk, particularly when LDL cholesterol is unexpectedly high, heart disease runs in the family, or atherosclerosis has developed early. It provides information in addition to a standard cholesterol panel.

How is the test performed?

A blood sample is collected from a vein and placed in a serum or plasma container. A laboratory then measures the cholesterol content of Lp(a) in the sample.

How do I prepare for the test?

Fasting is generally not required for Lp(a), but your clinician or laboratory may request it as part of a broader lipid panel. Follow the instructions provided, avoid strenuous exercise immediately before the draw, and do not stop prescribed medicines unless instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Lipoprotein(a) cholesterol

Frequently asked questions

Is this test the same as an LDL cholesterol test?
No. LDL cholesterol measures cholesterol in a broader group of low-density particles, while this test measures the cholesterol specifically carried by Lp(a).
Do I need to fast before this test?
Lp(a) measurement usually does not require fasting, although fasting may be requested when it is ordered with other cholesterol tests. Follow the laboratory's specific instructions.
Can diet and exercise lower lipoprotein(a)?
Lp(a) is strongly influenced by genetics, so diet and exercise generally do not lower it substantially. A clinician can still recommend these measures to reduce overall cardiovascular risk and address other cholesterol levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy