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Lipid-Derived Insulin Resistance (LP-IR) Score, Serum/Plasma (Calculated)

Published: August 9, 2026Updated: August 16, 2026

The LP-IR score is a calculated estimate of insulin resistance based on lipid-panel results. It may help assess metabolic and diabetes risk but does not diagnose diabetes.

Quick summary

["A higher LP-IR score generally suggests greater insulin resistance and increased risk of type 2 diabetes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
62255-5
Short code
LP-IR score SerPl
Synonyms
LP-IR score SerPl
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

The lipid-derived insulin resistance score, or LP-IR score, is a calculated estimate of how well the body responds to insulin. It uses information from a lipid panel, including triglycerides and HDL cholesterol, rather than directly measuring insulin.

Why might I need this test?

A clinician may use this test to help evaluate insulin resistance, especially in someone with excess weight, high blood pressure, abnormal cholesterol, a family history of type 2 diabetes, or other risk factors. It can provide additional information alongside glucose, insulin, and other metabolic tests.

How is the test performed?

The score is calculated from results of a serum or plasma lipid panel using a standard formula. If blood must be collected, a sample is drawn and the required cholesterol and triglyceride measurements are performed in the laboratory.

How do I prepare for the test?

Follow the fasting instructions provided for the lipid panel, because eating can change triglyceride and cholesterol results. If fasting is requested, drink only water during the specified period unless the laboratory instructs otherwise, and do not stop medications unless your clinician tells you to.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

LP-IR score

Frequently asked questions

Does an LP-IR score diagnose diabetes?
No. It estimates insulin resistance and may help identify risk, but diagnosis usually requires blood glucose testing and, when appropriate, an insulin or other confirmatory evaluation.
Is the LP-IR score the same as a glucose or insulin test?
No. The LP-IR score is calculated from lipid-panel information, while glucose and insulin tests directly measure substances involved in blood sugar regulation.
What can change my LP-IR score?
Fasting status, cholesterol-lowering or diabetes medicines, body weight, diet, and the accuracy of the underlying lipid results can all affect the score. Your clinician can explain how it fits with your other tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy