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Plasma Lipoprotein(a) Concentration (Lp(a))

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of lipoprotein(a) in your blood, a type of lipoprotein that includes cholesterol and a unique protein called apolipoprotein(a). Lp(a) is linked to increased risk of heart disease and blood clots.

Quick summary

["Lp(a) levels may help assess your risk for cardiovascular problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
80255-3
Short code
L-PLB Pr on Angio
Synonyms
L-PLB Pr on Angio
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
angiogram
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Lp(a)?

Lp(a) is a lipoprotein particle that combines cholesterol with apolipoprotein(a). It’s distinct from other lipoproteins like LDL (low-density lipoprotein) because of its unique protein component. Lp(a) can be inherited and may persist at higher levels throughout life.

Why Might You Need This Test?

Your healthcare provider may order this test if you have a family history of heart disease, stroke, or blood clots, or if you have conditions like atherosclerosis (hardening of the arteries) that increase your risk. It may also be part of a broader cardiovascular risk assessment.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is then processed to measure Lp(a) concentration using a specialized immunoassay method. Results are typically available within a few days.

What Do the Results Mean?

Higher Lp(a) levels may indicate an increased risk of cardiovascular events, such as heart attacks or strokes. However, results alone don’t diagnose a condition—they’re used alongside other factors like lifestyle, medical history, and other tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Lipoprotein(a) (Lp(a))

Frequently asked questions

What causes high Lp(a) levels?
High Lp(a) levels can be influenced by genetics—it’s often inherited—and may not change significantly with lifestyle modifications like diet or exercise. However, some studies suggest certain medications or conditions might affect levels, though research is ongoing.
Can lifestyle changes lower Lp(a) levels?
While lifestyle factors like diet, exercise, and smoking status can influence other cholesterol types (e.g., LDL), Lp(a) levels are less responsive to these changes. Genetic testing or specialized treatments may be explored for persistent high levels.
Is Lp(a) tested as part of a routine blood panel?
No, Lp(a) is not routinely included in standard cholesterol panels. It’s typically ordered based on specific clinical needs, such as a family history of cardiovascular disease or evaluation of unexplained vascular risks.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy