Serum/plasma mass concentration of lipoprotein-associated phospholipase A2 (Lp-PLA₂)
This test measures the activity of an enzyme called lipoprotein-associated phospholipase A2 (Lp-PLA₂), which is linked to inflammation and cardiovascular risk.
["Helps assess inflammation and risk of heart disease."]
Key facts at a glance
- LOINC
- 86951-1
- Short code
- Lp-PLA2 SerPl-cCnc
- Synonyms
- Lp-PLA2 SerPl-cCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is Lp-PLA₂ Used For?
Lp-PLA₂ is primarily measured to evaluate cardiovascular risk, particularly in patients with a history of heart disease or high cholesterol. It may also be used to monitor inflammation in certain conditions.
How Is the Test Performed?
A blood sample is drawn from a vein, usually in the arm. The blood is then processed to separate serum or plasma, where the enzyme activity is measured using specialized laboratory techniques.
Why Might You Need This Test?
Your healthcare provider may order this test if you have symptoms or risk factors for heart disease, such as high blood pressure, high cholesterol, diabetes, or a family history of cardiovascular issues. It may also be used to guide treatment decisions for managing inflammation.
What Does a High or Low Result Mean?
Higher levels of Lp-PLA₂ activity may indicate increased inflammation and a higher risk of heart disease. However, results should be interpreted alongside other clinical factors, including medical history, symptoms, and other lab tests.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Lp-PLA₂ is an enzyme found on certain types of lipoproteins (fat particles in the blood). Elevated activity is associated with atherosclerosis (plaque buildup in arteries) and increased cardiovascular risk. While not a definitive diagnostic test, it can provide additional insight into inflammation and help tailor treatment plans for patients at higher risk.
Short name
Lp-PLA₂ (Phospholipase A2 Activity)
Frequently asked questions
Why was this test ordered for me?
What does the test result mean for my health?
Do I need to prepare for this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy