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C-reactive protein (CRP) by nephelometry (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of C-reactive protein, a protein produced by the liver in response to inflammation in your body.

Quick summary

["CRP helps doctors assess inflammation, often used to monitor conditions like infections, autoimmune diseases, or after surgery."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
38277-0
Short code
LPT 0.5 ug/mL CA Bld-aCnc
Synonyms
LPT 0.5 ug/mL CA Bld-aCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for signs of inflammation, monitor chronic conditions like arthritis or heart disease, or evaluate responses to treatments. It can also help identify infections or other inflammatory processes in your body.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if it’s drawn from fasting serum, but this is less common for CRP. Avoid strenuous activity or recent illness for 24 hours before testing to get more accurate results.

What Happens During the Test?

A small needle will be used to draw blood from a vein in your arm. You may feel a brief pinch, but it usually doesn’t cause significant discomfort. The blood sample is then sent to a lab for analysis using a nephelometry method to measure CRP levels.

What Do Results Mean?

Higher CRP levels often indicate inflammation, but they can also be elevated due to other factors like infection, stress, or certain medications. Your results will be compared to your clinical picture and other tests to determine their significance.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: whole-blood

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated CRP is a general marker of inflammation and can signal conditions such as infections (e.g., pneumonia, urinary tract infections), autoimmune diseases (e.g., rheumatoid arthritis, lupus), or cardiovascular risks. It may also be used to monitor disease activity or treatment response in chronic conditions. However, CRP alone doesn’t diagnose a specific condition—it’s part of a broader evaluation.

Short name

CRP (Nephelometry)

Frequently asked questions

How often should I get this test?
The frequency depends on your health condition and treatment plan. Your doctor may recommend it monthly, quarterly, or annually, or more often if you have an active inflammatory condition or recent symptoms.
Can lifestyle changes affect CRP levels?
Yes, lifestyle factors like diet (e.g., Mediterranean diet), exercise, weight management, and smoking can influence CRP levels. Reducing inflammation through these changes may lower CRP, but results vary by individual.
What if my CRP is high but I don’t have obvious symptoms?
A high CRP may indicate subclinical inflammation—silent inflammation that isn’t causing obvious symptoms. Your doctor may investigate further with additional tests or a review of your medical history to identify potential causes, such as undiagnosed infections, autoimmune activity, or metabolic issues.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy