Serum or plasma concentration of bile acids (total)

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like jaundice (yellowing of skin/eyes), unexplained fatigue, abdominal pain, or if they suspect liver disease, bile duct obstruction, or metabolic disorders. It can also be used to monitor conditions like cirrhosis, cholestasis, or certain genetic disorders affecting bile acid metabolism.

What to Expect Before the Test

No special preparation is typically needed, but you may be asked to fast for 8–12 hours before the draw if your lab uses a specific method. Avoid consuming foods high in bile acids (e.g., fatty foods) for 24 hours prior if instructed. Bring any medications you’re taking, as some may affect results.

What Happens During the Test

A healthcare professional will collect a blood sample from a vein in your arm. The sample is sent to the lab, where it’s analyzed to measure total bile acids using a sensitive detection method (likely immunoassay or similar). The process takes about 30 minutes, and you can return to normal activities afterward.

What the Results Mean

Results are compared to a reference range specific to your lab, but elevated levels may indicate conditions like biliary obstruction, liver disease, or certain metabolic syndromes. Very low levels could suggest rare genetic disorders or malabsorption issues. Your provider will discuss findings in the context of your symptoms and medical history.