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Total Protein with Albumin/Globulin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein levels and evaluates the balance between albumin and globulin proteins, which can help identify issues like kidney disease, liver problems, or nutritional deficiencies.

Quick summary

["Assesses protein balance and potential organ or nutritional concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58718-8
Short code
LPT 10 ug CA Act/Nor Bld
Synonyms
LPT 10 ug CA Act/Nor Bld
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Total protein in your blood includes albumin and globulin proteins. Albumin helps maintain fluid balance in your body, while globulins support immune function and blood clotting. This test provides a ratio to help doctors spot imbalances that may signal health problems.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like swelling, unexplained weight loss, fatigue, or signs of kidney or liver disease. It can also help monitor chronic conditions like chronic kidney disease or malnutrition.

Common Conditions Monitored

High or low protein levels may indicate conditions such as liver disease, kidney problems, severe infections, or malnutrition. The albumin-to-globulin ratio can also reflect immune function or inflammation.

How Is This Test Done?

A small blood sample is taken from your arm. The blood is sent to a lab, where it is analyzed to measure total protein and the ratio of albumin to globulin proteins.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: whole-blood

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein Ratio

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 1 to 3 business days, depending on your lab’s processing time. Your doctor will discuss the findings with you during your follow-up visit.
What are the normal values for this test?
There are no specific numeric ranges provided here since they vary by lab and test method. Your doctor will interpret results in relation to your overall health and medical history.
Can I eat or drink anything before this test?
No special preparation is needed for this test. You may eat and drink normally as scheduled, unless your doctor has instructed otherwise.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy