Skip to content

Total Bilirubin with Direct and Indirect Fractions (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your body’s breakdown products of hemoglobin, helping assess liver function and bile flow. It includes both indirect (unconjugated) and direct (conjugated) fractions.

Quick summary

["This test helps diagnose liver issues, bile duct blockages, or hemolytic conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
38284-6
Short code
LPT 19.3 ug/mL TT Bld-aCnc
Synonyms
LPT 19.3 ug/mL TT Bld-aCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters for Your Health

Your liver processes bilirubin, a waste product from red blood cell breakdown. High levels can signal problems like jaundice, liver disease, or gallbladder issues. The direct fraction checks if bilirubin is properly processed and excreted.

How the Test Works

Blood is drawn and analyzed to separate bilirubin into indirect (not yet processed by the liver) and direct (already processed) forms. Results help pinpoint whether the issue lies in red blood cell breakdown, liver function, or bile flow.

Common Conditions This Test Helps Identify

Elevated indirect bilirubin may indicate hemolytic anemia (rapid red blood cell destruction), while high direct bilirubin suggests liver disease, bile duct obstruction, or Gilbert’s syndrome (a mild genetic condition).

What to Expect Before the Test

No special preparation is needed, but inform your provider if you’re taking medications that affect liver function or have a history of bleeding disorders.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: whole-blood

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Bilirubin Profile

Frequently asked questions

What does a high or low bilirubin level mean?
High levels often require further testing to determine the cause (e.g., liver scans, blood counts). Low levels are less common but may signal iron deficiency or other metabolic issues.
Can diet affect bilirubin results?
Dietary changes alone won’t alter test results, but certain foods (like excessive alcohol or fatty foods) may influence liver function indirectly. Follow your provider’s advice for dietary considerations if applicable.
How soon will I get my results?
Results are typically available within 1–3 business days, depending on your lab. Your healthcare provider will discuss them with you during your follow-up.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy