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C-reactive protein (CRP) with high-sensitivity measurement in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This blood test measures a protein produced by your body in response to inflammation, helping assess low-level inflammation that may not be detected by other tests.

Quick summary

["High-sensitivity CRP helps track subtle inflammatory activity, often used alongside other tests for risk assessment."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
69014-9
Short code
LPT CA max/CD45 Bld FC-NFr
Synonyms
LPT CA max/CD45 Bld FC-NFr
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
85610
SNOMED
396252006
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate the risk of heart disease, monitor chronic conditions like arthritis or inflammatory bowel disease, or check for signs of infection or inflammation after surgery or trauma. It can also help guide treatment decisions for conditions like autoimmune diseases.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Results are not provided as a single number but are compared to general reference ranges for healthy adults. Higher levels may indicate inflammation, while lower levels suggest reduced inflammation. Your provider will interpret results in the context of your overall health.

Common Conditions Monitored

This test is often used to monitor conditions like cardiovascular disease risk, rheumatoid arthritis, lupus, or other inflammatory disorders. It may also help assess post-surgical healing or response to treatment for infections.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: whole-blood

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: High-sensitivity CRP is a marker of systemic inflammation. While it doesn’t diagnose specific conditions, elevated levels may signal underlying inflammation that could affect heart health, joint health, or other organ systems. It’s typically used alongside other tests for a more complete picture.

Short name

High-Sensitivity CRP (hs-CRP)

Frequently asked questions

What causes CRP levels to change?
CRP levels can rise due to infections, injuries, surgeries, or chronic inflammatory diseases. They may also fluctuate with stress, certain medications, or lifestyle factors like smoking or poor diet. Your provider will consider these factors when reviewing your results.
How often should I get this test?
Frequency depends on your health condition and provider’s recommendations. Some people get it every few months to monitor chronic inflammation, while others may need it only occasionally for risk assessment or treatment follow-up.
Can diet or lifestyle affect CRP levels?
Yes, diet, exercise, and weight management can influence CRP levels. Reducing processed foods, increasing omega-3s (found in fish), and maintaining a healthy weight may help lower inflammation. Always discuss lifestyle changes with your provider before making major adjustments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy