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Serum/plasma concentration of total protein by nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes important proteins like albumin and globulins that help maintain fluid balance and support immune function.

Quick summary

["Your blood protein levels can indicate overall health and help diagnose conditions like dehydration, kidney disease, or liver problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58727-9
Short code
LPT PHA Bld-Imp
Synonyms
LPT PHA Bld-Imp
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order a total protein test to check for signs of health issues, such as infections, kidney or liver disease, malnutrition, or certain types of cancer. It can also help monitor conditions like multiple myeloma or chronic kidney disease.

What to Expect Before the Test

No special preparation is needed for this test. You may be asked to fast for 8–12 hours before the blood draw if your doctor recommends it, but this is not always required for total protein levels alone.

How the Test Is Performed

A healthcare provider will draw blood from a vein in your arm using a small needle. You may feel a brief pinch, but the procedure usually takes just a few minutes. The blood sample is then sent to a lab for analysis.

Possible Results and Interpretation

Results are typically reported as a numerical value (e.g., grams per deciliter). While reference ranges vary by lab, low levels may suggest malnutrition, kidney disease, or liver problems, while very high levels could indicate conditions like multiple myeloma or severe dehydration.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: whole-blood

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes low total protein levels?
Low total protein levels can result from conditions like chronic kidney disease, liver disease, malnutrition, severe infections, or certain autoimmune disorders. Your doctor may also check for conditions like protein-losing gastrointestinal disorders or nephrotic syndrome.
What causes high total protein levels?
High total protein levels may occur with conditions such as multiple myeloma, severe dehydration, chronic infections, or inflammatory diseases. Rarely, it could also be linked to certain cancers or genetic disorders affecting protein synthesis.
How often should I get this test?
The frequency depends on your health status and medical needs. Your doctor may recommend this test periodically if you have a chronic condition like kidney disease, liver disease, or cancer. Follow-up may also be needed if you’re undergoing treatment for conditions that affect protein levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy