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Serum/plasma protein electrophoresis (qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood using an electrical charge to separate them. It helps identify abnormalities in protein distribution, which can signal conditions like multiple myeloma, liver disease, or other disorders.

Quick summary

["This test helps doctors check for unusual protein patterns that may indicate health issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58722-0
Short code
LPT PW Bld-Imp
Synonyms
LPT PW Bld-Imp
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

Electrophoresis separates proteins based on their size and electrical charge. The test detects five main protein bands: albumin, alpha-1 globulins, alpha-2 globulins, beta globulins, and gamma globulins. Abnormal patterns may appear as extra bands, missing bands, or shifts in normal positions.

Why It’s Done

Doctors order this test to diagnose or monitor conditions like multiple myeloma, lymphoma, liver disease, kidney disease, or certain autoimmune disorders. It may also help evaluate protein-related symptoms such as swelling, fatigue, or unexplained weight changes.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum or plasma for testing. No special preparation is needed, but fasting may be advised depending on your doctor’s instructions.

What to Expect Before the Test

You may feel slight discomfort during the blood draw, but it typically takes a few minutes. Avoid eating or drinking for 8–12 hours before if fasting is required. Wear comfortable clothing and let your doctor know about any medications or allergies.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: whole-blood

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Protein Electrophoresis (Serum/Plasma)

Frequently asked questions

What abnormal results might mean?
Abnormal electrophoresis results can indicate conditions such as multiple myeloma (extra gamma globulin bands), liver disease (reduced albumin), or chronic inflammation (elevated alpha-2 or beta globulins). A doctor will interpret results in the context of your symptoms and medical history.
How long will I need to wait for results?
Results are usually available within 24–48 hours, depending on lab processing times. Your doctor will discuss them with you during a follow-up visit.
Can I eat or drink before this test?
Check with your doctor or lab for fasting instructions, as some tests require an 8–12 hour fast before drawing blood.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy