Serum or plasma concentration of total bilirubin

Why is bilirubin important?

Bilirubin is a byproduct of hemoglobin breakdown in the body. Normally, it’s processed by the liver and excreted in bile. High levels may indicate problems like liver disease, gallbladder issues, or hemolytic anemia, while low levels might suggest certain liver disorders or bile flow problems.

What causes bilirubin to change?

Bilirubin levels can rise due to overproduction (e.g., from red blood cell destruction) or impaired liver/bile duct function. Conditions like hepatitis, cirrhosis, or blockages in the bile ducts can lead to elevated bilirubin, causing jaundice (yellowing of skin/eyes). Conversely, very low levels may occur in rare genetic disorders or liver dysfunction.

How is this test performed?

A blood sample is drawn, and the serum or plasma is analyzed using a chemical method to measure bilirubin concentration. The test is quick and typically done in a lab setting.

What might my results mean?

Results are usually reported as a numerical value (e.g., mg/dL) compared to a reference range. Elevated levels may prompt further testing for liver or bile system conditions, while low levels may require investigation into underlying metabolic or genetic factors.