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Prostate-Specific Antigen (PSA) in Serum by Immunoassay Probe

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of prostate-specific antigen (PSA) in your blood, a protein produced mainly by the prostate gland. PSA helps doctors assess prostate health, including detecting early signs of prostate cancer or other prostate issues.

Quick summary

["PSA blood tests are often used to monitor prostate health and guide decisions about further testing or treatment."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63425-3
Short code
LT Spec Ql NAA+probe
Synonyms
LT Spec Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might You Need This Test?

Your doctor may recommend a PSA test if you have symptoms like urinary problems, pain in the pelvic area, or if you’re at higher risk for prostate issues due to age, family history, or other medical conditions. It can also be used during routine check-ups for men over 40 or as part of screening for prostate cancer.

What Does a PSA Test Measure?

PSA is a protein that helps liquefy semen during ejaculation. While most PSA comes from the prostate, small amounts can also come from other parts of the male reproductive system. Elevated PSA levels may suggest prostate inflammation, infection, benign prostatic hyperplasia (BPH), or cancer, though other factors can influence results.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is then sent to a lab where it’s analyzed using an immunoassay probe to detect PSA levels. The test typically takes a few hours to complete, and results are usually available within a day or two.

What Do the Results Mean?

PSA results alone don’t diagnose prostate cancer—they’re part of a broader evaluation. Your doctor will consider your PSA level, symptoms, age, family history, and other test results (like a digital rectal exam or imaging studies) to determine next steps. Very low PSA levels may indicate no issues, while very high levels may prompt further testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

PSA Serum

Frequently asked questions

What Are Common Causes of Elevated PSA Levels?
Elevated PSA can result from conditions like prostate inflammation (prostatitis), benign prostatic hyperplasia (BPH), infections, or prostate cancer. However, other factors such as recent ejaculation, exercise, or certain medications can temporarily affect PSA levels.
How Often Should I Get a PSA Test?
The frequency of PSA testing depends on your age, health history, and risk factors. The U.S. Preventive Services Task Force recommends discussing testing options with your doctor, as guidelines vary. For men with no symptoms or risk factors, testing may be less frequent than for those at higher risk.
Can Diet or Lifestyle Affect PSA Levels?
Yes, certain foods, supplements, or lifestyle habits—like high-fat diets, vitamin E supplements, or exercise—may influence PSA levels. It’s important to discuss any changes with your doctor to avoid misleading results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy