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Lipoprotein(a) concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of lipoprotein(a), a type of cholesterol-like substance that can increase your risk of heart disease and blood clots.

Quick summary

["Lipoprotein(a) levels help assess cardiovascular risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26463-0
Short code
LUC NFr Bld
Synonyms
LUC NFr Bld
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is Lipoprotein(a)?

Lipoprotein(a) is a unique lipoprotein particle that combines cholesterol with a protein called apolipoprotein(a). While it shares some traits with other cholesterol-related particles, its presence is linked to higher risks of artery blockages and blood clots. Unlike traditional cholesterol tests, lipoprotein(a) is not affected by diet or exercise, making it a more stable marker for long-term cardiovascular health.

Why Might You Need This Test?

Doctors may order lipoprotein(a) testing if you have a family history of heart disease, stroke, or blood clots, certain genetic conditions (like familial hypercholesterolemia), or if you’ve already had cardiovascular events. It can also be part of routine cardiovascular risk assessments, especially in individuals with elevated LDL cholesterol or other risk factors.

How Is the Test Done?

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab for analysis using a specialized immunoassay method to measure lipoprotein(a) concentration.

What Do Results Mean?

Results provide a specific measurement of lipoprotein(a) in the blood, though reference ranges vary by lab. Higher levels may indicate increased cardiovascular risk, prompting further evaluation or lifestyle or medical interventions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Lp(a) (Lipoprotein(a))

Frequently asked questions

Why do some people with normal cholesterol levels still have high lipoprotein(a) levels?
Lipoprotein(a) is genetically determined and doesn’t change with diet or exercise. Some people inherit higher levels without obvious risk factors, so it’s important for long-term heart health monitoring.
Can lifestyle changes lower lipoprotein(a) levels?
No, unlike LDL cholesterol, lipoprotein(a) levels are not affected by diet, exercise, or weight loss. However, managing other cardiovascular risk factors (like blood pressure and smoking) can help reduce overall risk.
Is lipoprotein(a) testing covered by insurance?
Coverage depends on your insurance plan and clinical indication. Some insurers may require a specific diagnosis (e.g., family history of cardiovascular disease) to cover the test. Always check with your provider or insurance company.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy