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Autoantibody Profile to Screen for Connective Tissue Disease (e.g., Lupus, Scleroderma) – Serum

Published: August 9, 2026Updated: August 16, 2026

This blood test checks for certain proteins (antibodies) that your immune system may mistakenly produce when fighting healthy tissue, which can signal conditions like lupus or other autoimmune diseases.

Quick summary

["Identifies potential autoimmune conditions that may require further evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
74396-3
Short code
LUC NFr BldCo Auto
Synonyms
LUC NFr BldCo Auto
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
automated-count
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects a panel of antibodies, including those that may target proteins in your joints, skin, kidneys, or blood vessels. These antibodies can be part of a broader autoimmune response.

Why It’s Ordered

Your healthcare provider may recommend this test if you have symptoms like joint pain, unexplained fatigue, rash, or other signs of an autoimmune condition. It’s also used as part of routine monitoring for certain chronic illnesses.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the blood draw if your lab requires it. Wear a loose shirt for easy access.

What to Expect During the Test

A healthcare professional will insert a small needle into your arm to draw blood. You may feel a brief pinch, but it usually doesn’t cause significant discomfort. The process takes about 5 minutes.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Autoantibody Screen

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains elevated levels of certain antibodies that may signal an autoimmune response. This doesn’t mean you have a disease yet, but it may prompt further testing to explore possible causes.
Will I need more tests if this test is positive?
Yes, additional tests may be recommended to narrow down the cause. These could include more specific antibody tests, imaging, or other bloodwork to check organ function or inflammation markers.
Can lifestyle changes affect these antibody levels?
Some autoimmune conditions may be influenced by diet, stress, or other lifestyle factors, but antibody levels are primarily measured in the lab. Your provider can discuss how to manage symptoms while awaiting results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy