Vasodilator-Induced Stress Test with Maximal Treadmill Exercise (Serum Creatine Kinase - Total)

What Is Creatine Kinase (CK)?

Creatine kinase (CK) is an enzyme found in heart, skeletal, and smooth muscle cells. It plays a role in energy production. When you exercise, your muscles use energy, and CK helps convert adenosine triphosphate (ATP) into energy your body can use. Elevated CK levels may indicate muscle damage or stress, including in the heart.

Why Is This Test Done During Exercise?

This test is performed during a stress test, where you walk on a treadmill until you reach your maximum effort. The exercise helps identify how your heart responds to physical stress, which can reveal potential issues like coronary artery disease or heart muscle damage.

What Does the Test Measure?

The test measures total CK levels in your blood after exercise. CK is broken down into three subtypes (CK-MB, CK-MM, CK-BB), but this test reports the total CK concentration. Elevated total CK may suggest muscle damage, inflammation, or other conditions affecting muscle function.

When Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like chest pain, shortness of breath, or fatigue during exercise, or if you’re at risk for heart disease. It’s also used to monitor conditions like heart attacks, muscle disorders, or to evaluate recovery from injuries.