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C-reactive protein (CRP) by nephelometry (high-sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This blood test measures a protein called C-reactive protein, which your body produces in response to inflammation. It helps assess low-level inflammation that may not be obvious from other tests.

Quick summary

["This test helps track subtle inflammation, often used alongside other tests to monitor conditions like heart disease risk or autoimmune activity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104150-8
Short code
LV EF US.2D.A3C+biplane
Synonyms
LV EF US.2D.A3C+biplane
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
us-d-a-c-calculated-by-biplane-method
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Healthcare providers use high-sensitivity CRP to evaluate the risk of heart disease, monitor chronic conditions like rheumatoid arthritis or lupus, or check for signs of inflammation after surgery or injury. It’s also sometimes used to guide treatment decisions for conditions where inflammation plays a role.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood, similar to other blood tests. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Results are reported in milligrams per liter (mg/L). Higher levels may indicate inflammation, but they don’t always pinpoint the cause. Your provider will interpret results in the context of your overall health and symptoms.

Common Conditions Monitored

Elevated CRP levels can signal conditions like infections, autoimmune diseases (e.g., rheumatoid arthritis), or cardiovascular risks. It’s not a standalone test but often used alongside other markers for a fuller picture.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

High-sensitivity CRP (hs-CRP)

Frequently asked questions

What does a high CRP level mean?
A high CRP level suggests inflammation is present in your body, which could be due to infections, injuries, autoimmune conditions, or other health issues. Your provider will discuss what this means for you based on your symptoms and medical history.
How often should I get this test?
Your provider will determine how often you need this test based on your health needs—whether for monitoring a chronic condition, assessing risk, or evaluating treatment response. Follow their guidance.
Can diet or exercise affect CRP levels?
Yes, lifestyle factors like diet, exercise, and smoking can influence CRP levels. Eating a heart-healthy diet, staying active, and avoiding smoking may help lower inflammation over time. Ask your provider about personalized recommendations.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy