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Lipoprotein(a) [Lp(a)] concentration in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of lipoprotein(a) in your blood, a type of cholesterol-related protein that may increase your risk of heart disease.

Quick summary

["Lipoprotein(a) levels help assess cardiovascular risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77889-4
Short code
LV EF US.M-mode+cube
Synonyms
LV EF US.M-mode+cube
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
us-m-mode-calculated-by-cube-method
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Lipoprotein(a)?

Lipoprotein(a) is a unique lipoprotein particle that combines cholesterol with a protein called apolipoprotein(a). While it shares some traits with cholesterol, it behaves differently in the body and is linked to higher risks of blood clots and heart disease. High levels may be inherited but can also be influenced by lifestyle factors.

Why Might You Need This Test?

Your doctor may order this test if you have a family history of heart disease, stroke, or blood clots, or if you have conditions like high cholesterol, diabetes, or hypertension. It may also be used to monitor risk in people with certain genetic conditions.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then sent to a lab for analysis using a specialized immunoassay method to measure lipoprotein(a) levels.

What Do Results Mean?

Results are reported in milligrams per deciliter (mg/dL) or other units. While there are no strict reference ranges for everyone, higher levels may indicate increased cardiovascular risk, prompting further evaluation or lifestyle changes.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated lipoprotein(a) levels are associated with an increased risk of atherosclerosis (plaque buildup in arteries), coronary artery disease, and blood clots. It is considered an independent risk factor for cardiovascular events, though it is not always fully modifiable. Some research suggests it may be influenced by genetics, but lifestyle factors like diet and exercise may also play a role.

Short name

Lp(a) Level

Frequently asked questions

What causes lipoprotein(a) levels to be high?
High lipoprotein(a) levels can be genetic, meaning you may inherit them from family members. However, certain health conditions, such as kidney disease, obesity, or smoking, may also contribute. Some medications, like certain cholesterol-lowering drugs, might affect levels, but this is less common.
Can lifestyle changes lower lipoprotein(a) levels?
While lifestyle changes like diet, exercise, and quitting smoking can help manage other cardiovascular risk factors, there is limited evidence that they significantly lower lipoprotein(a) levels. Genetic factors play a major role, so lifestyle modifications may not always reduce levels enough to prevent cardiovascular events.
Is this test covered by insurance?
Coverage depends on your insurance plan and the reason for the test. If your doctor orders it for a specific medical reason (e.g., cardiovascular risk assessment), check with your insurer. Some plans may cover it if it’s part of a broader cardiovascular evaluation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy