Lipoprotein Subfraction Analysis by Electrophoresis (Serum)

Why This Test Matters for Heart Health

Standard cholesterol tests (like LDL and HDL) give a general picture, but this test provides a more detailed breakdown of different lipid particles. Smaller, denser particles (like LDL subtypes) can be more harmful to your arteries than larger ones, even if overall cholesterol levels seem normal.

What the Test Measures

This test identifies specific lipoprotein classes (e.g., LDL subtypes, VLDL, chylomicrons) using electrophoresis, a method that separates blood components by size and density. Results help assess how your body processes fats and whether certain particles are more likely to cause plaque buildup in arteries.

When You Might Need This Test

Your doctor may recommend this test if you have a family history of heart disease, high cholesterol, or other risk factors like diabetes or high blood pressure. It’s also used in research or specialized care for conditions like familial hypercholesterolemia.

Preparation for the Test

No special preparation is needed, but you should avoid eating or drinking anything (except water) for 12 hours before the test. Fasted blood samples provide more accurate results for lipid analysis.