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Lymphocyte count in cerebrospinal fluid (CSF)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of white blood cells called lymphocytes found in your spinal fluid. Lymphocytes are a type of immune cell that help protect your body from infections.

Quick summary

["Lymphocytes in spinal fluid can help diagnose or monitor certain conditions affecting the brain and spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26475-4
Short code
Lymphocytes # CSF
Synonyms
Lymphocytes # CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms like headaches, neck stiffness, fever, or neurological issues that could suggest an infection, inflammation, or other condition affecting the central nervous system. It might also be used to monitor treatment progress for conditions such as meningitis, multiple sclerosis, or certain cancers.

What to Expect Before the Test

You’ll typically have a small needle inserted into your lower back to collect a sample of spinal fluid. The procedure is usually quick and may cause mild discomfort, but you’ll be given local anesthesia to numb the area.

What the Test Results Mean

The results show the count of lymphocytes (a type of white blood cell) in the fluid. Elevated levels may indicate an infection, inflammation, or other immune-related conditions. Lower-than-expected levels might suggest certain neurological disorders or immune deficiencies.

Common Conditions Monitored

This test helps diagnose or track conditions like meningitis, encephalitis, multiple sclerosis, lymphoma, or other immune-related diseases affecting the central nervous system.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Elevated or Low Lymphocyte Counts

Short name

CSF Lymphocyte Count

Frequently asked questions

What Does a Normal Range Mean for Me?
There’s no single ‘normal’ range for CSF lymphocyte counts because it depends on your overall health, the reason for testing, and other factors. Your results will be interpreted by your doctor in the context of your symptoms and medical history.
How Often Should I Get This Test?
Your doctor will determine how often you need this test based on your condition. Some people may need it once, while others may require follow-up tests over time to monitor changes.
Can I Eat or Drink Before This Test?
You can eat and drink normally before this test, as it doesn’t require fasting. However, inform your doctor about any medications or supplements you’re taking, as they may affect the results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy