Lymphocyte Count in Cerebrospinal Fluid (Manual Cell Differentiation)

Why Is This Test Done?

Your doctor may order this test if you have symptoms like severe headaches, neck stiffness, fever, confusion, or neurological issues that could indicate an infection, inflammation, or other conditions affecting the brain or spinal cord. It’s often used alongside other tests to guide treatment decisions.

What Does the Test Involve?

A small sample of your CSF is collected through a procedure called a lumbar puncture (spinal tap). The sample is then examined under a microscope to count and identify different types of white blood cells, including lymphocytes. This manual method provides detailed differentiation of cell types.

What Are Normal Results?

Normal results vary by individual and clinical context. Typically, a low or abnormal lymphocyte count in CSF may suggest infection, autoimmune disease, or other neurological conditions, but interpretation depends on your overall health and symptoms.

What Are Possible Causes of Abnormal Results?

Elevated lymphocyte counts in CSF can be linked to conditions such as viral meningitis, certain types of encephalitis, multiple sclerosis, or other inflammatory or infectious processes in the nervous system. Low counts may indicate conditions like Guillain-Barré syndrome or other immune-mediated disorders.