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Lymphocyte Count (Manual Differential Count of Blood Cells)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of lymphocytes, a type of white blood cell, in your blood. It helps assess immune function and identify conditions affecting white blood cell counts.

Quick summary

Lymphocytes are key to your immune system; this test helps track their levels for health monitoring or diagnosis.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14822-1
Short code
Lymphocytes NFr Snv Manual
Synonyms
Lymphocytes NFr Snv Manual
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to evaluate immune health, diagnose infections, check for blood disorders, or monitor conditions like leukemia, HIV, or autoimmune diseases. It can also help determine response to treatments.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm or hand for a blood draw. If you’re nervous, let your healthcare provider know—they can help.

What the Test Results Mean

Results show the absolute count of lymphocytes (typically reported as cells per microliter). While reference ranges vary by lab, abnormal counts may signal immune issues or infections. Your doctor will interpret results in context of your health.

Common Conditions Linked to Lymphocyte Counts

Low lymphocyte counts may indicate immune suppression (e.g., HIV/AIDS, chemotherapy), chronic infections, or certain cancers. High counts could suggest inflammation, allergies, or overactive immune responses. Always discuss results with your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Lymphocyte counts are critical for diagnosing and managing immune-related disorders. They help guide treatment decisions, such as adjusting medications for patients with autoimmune diseases or infections.

Short name

Manual Lymphocyte Count

Frequently asked questions

How often will I need this test?
Frequency depends on your health condition. Some patients need it monthly, while others may only require it once yearly or as needed for monitoring.
Can I eat or drink before this test?
No special diet is required. You can eat and drink normally, but avoid caffeine or alcohol before your blood draw if your provider suggests it.
What if my lymphocyte count is outside the normal range?
Your doctor will explain what the result means and may recommend further tests or treatments. They’ll tailor advice to your specific situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy