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Lymphocyte Count (Manual Differential Count)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of lymphocytes, a type of white blood cell, in your blood. It helps assess immune function and identify conditions affecting your white blood cell counts.

Quick summary

["Lymphocytes are key to fighting infections and maintaining immune health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
32697-5
Short code
Lymphocytes # Snv Manual
Synonyms
Lymphocytes # Snv Manual
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate immune system health, diagnose conditions like infections, autoimmune diseases, or blood disorders, or monitor treatments for these conditions. It can also help determine if your immune system is overactive or underactive.

What Does the Test Involve?

A small blood sample is drawn from a vein, typically in your arm. The sample is then examined under a microscope by a trained technician to count and identify different types of white blood cells, including lymphocytes.

What Are Normal Results?

Normal results vary and are based on your overall health and medical history. Your results will be compared to standard reference ranges provided by your lab.

What Are Common Conditions Affecting Lymphocyte Count?

Low lymphocyte counts (lymphopenia) may be seen in conditions like HIV/AIDS, chemotherapy treatments, or severe infections. High lymphocyte counts (lymphocytosis) can indicate chronic infections, certain cancers, or autoimmune diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Lymphocyte Count

Frequently asked questions

What does a manual differential count mean differently than an automated blood count?
A manual differential count involves a technician examining each white blood cell under a microscope to count and classify lymphocytes and other cell types. An automated blood count uses technology to estimate these counts quickly but may not provide the same level of detail.
How often should I get this test?
Your healthcare provider will determine the frequency of this test based on your medical condition, treatment plan, and symptoms. Regular monitoring may be necessary for chronic illnesses or ongoing treatments.
Can lifestyle changes affect my lymphocyte count?
Yes, lifestyle factors such as diet, stress levels, and sleep quality can influence immune function. Maintaining a balanced diet, managing stress, and getting adequate rest may support healthy lymphocyte levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy