Lymphocyte T-Cell Receptor Alpha/Beta Double-Negative Subset, Whole Blood
A blood test that identifies and measures T lymphocytes lacking both alpha- and beta-chain T-cell receptors, a specialized immune-cell subset.
["This test measures a specialized subset of T cells that may provide information about immune-system development or function."]
Key facts at a glance
- LOINC
- 101414-1
- Short code
- Lymphocyte TCR A B dbl neg sub pnl Bld
- Synonyms
- Lymphocyte TCR A B dbl neg sub pnl Bld
- Category
- liver
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures a specialized group of T lymphocytes, or T cells, that lack both alpha- and beta-chain T-cell receptors. These cells are often called alpha/beta double-negative T cells and are evaluated using a sample of whole blood.
Why might I need this test?
A clinician may order this test when evaluating unusual lymphocyte findings, symptoms related to immune-system function, or suspected inherited conditions affecting T-cell development. It may also be used to follow certain immune disorders.
How is the test performed?
A blood sample is sent to the laboratory, where the lymphocytes are identified and the double-negative T-cell subset is counted or reported as a proportion of the relevant cells. The laboratory may include this measurement as part of a broader lymphocyte subset panel.
How do I prepare for the test?
This test usually requires no fasting or special preparation. Follow the instructions provided by the ordering clinician or laboratory, particularly if other blood tests are being performed at the same visit.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Results are interpreted along with the total lymphocyte count, other T-cell subsets, the person's symptoms, and medical history. A reduced number or proportion of these cells may occur with impaired thymic or T-cell development, while an increased proportion may be seen in some immune or inflammatory conditions. The finding is not diagnostic by itself and requires clinical interpretation.
Short name
TCR alpha/beta double-negative T cells
Frequently asked questions
What does alpha/beta double-negative mean?
Does an abnormal result mean I have a specific disease?
Is this the same as a general lymphocyte count?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy