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Lymphocyte and Monocyte Differential Screening Profile (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the relative proportions of lymphocytes and monocytes in your blood, often used as part of an initial evaluation for immune system function or infection.

Quick summary

["Understanding your blood cell types can help identify potential health concerns early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
54228-2
Short code
Lymphoma - CLL screen Pnl Spec FC
Synonyms
Lymphoma - CLL screen Pnl Spec FC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

A lymphocyte is a type of white blood cell critical for fighting infections and maintaining immunity. Monocytes are another white blood cell that helps remove debris and pathogens. This screening evaluates their combined presence and balance in your bloodstream, typically via a blood draw.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fatigue, frequent infections, unexplained weight loss, or signs of immune dysfunction. It can also be part of routine monitoring for chronic conditions or after exposure to certain illnesses.

Common Uses and Considerations

While not a diagnostic test for specific diseases, abnormal results may prompt further evaluation, such as additional blood tests, imaging, or a consultation with a specialist. Always discuss your results with your provider.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours if your blood is drawn early in the morning. Wear a loose shirt for easy access, and inform your provider about any medications or health conditions you have.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Lympho-Mono Screen

Frequently asked questions

How can I prepare for this test?
No specific preparation is required, but you may need to avoid certain medications or activities depending on your individual health status. Your healthcare provider will give you detailed instructions tailored to your situation.
What does a low or high lymphocyte/monocyte count mean?
Low counts may indicate immune suppression, infections, or certain medications. High counts could signal chronic inflammation, infections, or other underlying conditions. Results should be interpreted by your provider in the context of your overall health.
Can this test detect a specific disease?
This screening test does not diagnose diseases directly but helps identify potential imbalances in your immune system. Further testing may be needed to determine the exact cause of abnormal results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy