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Lymphocyte Count (with White Blood Cell Differential)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of lymphocytes (a type of white blood cell) and provides a breakdown of your total white blood cell count into different cell types, including lymphocytes, neutrophils, eosinophils, basophils, and monocytes.

Quick summary

["Understanding your immune cell balance helps doctors diagnose infections, inflammation, or immune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
30113-5
Short code
Lymphs IgG # WBC
Synonyms
Lymphs IgG # WBC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.5
Ref high
11
Critical range
2 N/A – 30 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85004
SNOMED
900000000000003002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters for Your Health

Lymphocytes are key players in your immune system. They help fight infections and recognize harmful substances. A differential count helps identify if your immune response is too strong (overactive), too weak (underactive), or if there’s an imbalance that could signal a condition like leukemia, HIV, or autoimmune disease.

How the Test Works

Blood is drawn and analyzed using automated technology that separates and counts different white blood cell types. The test may also check for abnormalities in cell size or shape.

Common Reasons for Testing

Doctors may order this test if you have symptoms like frequent infections, unexplained weight loss, fatigue, or swollen lymph nodes. It’s also used before treatments like chemotherapy to monitor immune function.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm for a few minutes to draw blood. If you’re nervous, let your doctor or nurse know—many practices offer distractions or numbing cream.

Reference range

Adult: 4.5-11.0 x 10^9/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Lymphocyte & WBC Differential

Frequently asked questions

What does a low or high lymphocyte count mean?
A low lymphocyte count may indicate immune suppression (e.g., from HIV, chemotherapy, or certain medications) or chronic infections. A high count could signal overactive immune responses (e.g., autoimmune diseases) or conditions like lymphoma.
How often should I get this test?
Your doctor will determine frequency based on your health needs. Regular checks may be needed if you have ongoing conditions like cancer, HIV, or autoimmune disorders.
Can lifestyle changes affect my results?
Yes—stress, poor sleep, or infections can temporarily alter white blood cell counts. Avoid heavy exercise or alcohol 24 hours before testing, and rest well the day before.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy