Lysosomal Autoantibody Profile (Serum)
This test measures antibodies that may target lysosomal enzymes, which are proteins involved in breaking down waste in cells. These antibodies can sometimes indicate an autoimmune condition affecting lysosomes.
["This test helps evaluate potential autoimmune responses linked to lysosomal dysfunction."]
Key facts at a glance
- LOINC
- 54009-6
- Short code
- Lysosome Ab Ser Ql IF
- Synonyms
- Lysosome Ab Ser Ql IF
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- if
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may recommend this test if you have symptoms like unexplained fatigue, organ dysfunction, or a history of autoimmune diseases. It could also be part of a broader evaluation for lysosomal storage disorders or connective tissue diseases.
What to Expect During the Test
A blood sample will be drawn from a vein in your arm. The sample is processed into serum and sent to a lab for analysis. Results are typically available within 3–7 business days.
Common Conditions Monitored
This test is not a routine screening but may be used in cases of suspected autoimmune diseases (e.g., systemic lupus erythematosus, rheumatoid arthritis) or lysosomal enzyme deficiencies. It helps identify antibodies that could affect lysosomal function.
What the Results Mean
Positive results suggest the presence of autoantibodies against lysosomal enzymes, which may indicate an autoimmune response. However, further testing and clinical correlation are needed to determine the cause of symptoms.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical significance: Elevated lysosomal autoantibodies may signal an autoimmune process targeting lysosomal enzymes, potentially linked to conditions like autoimmune pancreatitis, vasculitis, or certain connective tissue disorders. Results should be interpreted alongside clinical findings and other diagnostic tests.
Short name
Lysosome Autoantibodies
Frequently asked questions
What does a positive result mean?
Will this test be repeated if results are abnormal?
Can lifestyle changes affect this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy